Cancer Therapy: Preclinical Pazopanib Reveals a Role for Tumor Cell B-Raf in the Prevention of HER2þ Breast Cancer Brain Metastasis
نویسندگان
چکیده
Purpose: Brain metastases of breast cancer contribute significantly to patient morbidity and mortality. We have tested pazopanib, a recently approved antiangiogenic drug that targets VEGFR1, VEGFR2, VEGFR3, PDGFRb, PDGFRa, and c-kit, for prevention of experimental brain metastases and mechanism
منابع مشابه
Pazopanib reveals a role for tumor cell B-Raf in the prevention of HER2+ breast cancer brain metastasis.
PURPOSE Brain metastases of breast cancer contribute significantly to patient morbidity and mortality. We have tested pazopanib, a recently approved antiangiogenic drug that targets VEGFR1, VEGFR2, VEGFR3, PDGFRβ, PDGFRα, and c-kit, for prevention of experimental brain metastases and mechanism of action. EXPERIMENTAL DESIGN In vitro assays included B-Raf enzymatic assays, Western blots, and a...
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